Chagas

The main objectives of the Chagas Disease Research Network is to study and better understand the transmission dynamics of the parasite (Trypanosoma cruzi) in hyperendemic areas of central-western Venezuela, specifically in the states of Lara and Portuguesa. We currently work and collaborate in a number of molecular epidemiology studies of T. cruzi aimed to characterize T. cruzi isolates and it´s specific prevalent genotypes.

In addition, we carry out entomological evaluations and population genomics studies of triatomine involved in the transmission cycles of endemic and hyperendemic areas.

Along with the Zoonosis Network, we perform active surveillance programs focusing on the detection of T. cruzi infection in synanthropic mammals; and how these potential reservoirs mediate in domestic-peridomestic-zoonotic cycles.

Entomological evaluation and surveillance programs are carried out through community-based insect-surveillance campaigns, as part of our “Citizen Science” training projects.

Publications:

 2012

  1. Benain G., Paniz Mondolfi AE.
    The emerging role of Amiodarone and dronedarone in chagas disease. 

    Nature Rev.
    Date: August, 2012. For complete article.
  2. Paniz-Mondolfi AE, Pérez-Alvarez AM, Lanza G, Márquez E, Concepción JL.
    Amiodarone and itraconazole: a rational therapeutic approach for the treatment of chronic Chagas’ disease.
    Kargen AG.
    Date: May, 2009. For complete article.
  3. Benaim G, Hernandez-Rodriguez V, Mujica-Gonzalez S, Plaza-Rojas L, Silva ML, Parra-Gimenez N, Garcia-Marchan Y, Paniz-Mondolfi A, Uzcanga G.
    In vitro anti-Trypanosoma cruzi activity of dronedarone, a novel amiodarone derivative with an improved safety profile.
    Antimicrob Agents Chemother.
    Date: July, 2012 For complete article.